Selected Publications

Kristina Ames, Imit Kaur, Yang Shi, Meng Tong, Taneisha Sinclair, Shayda Hemmati, Shira G. Glushakow-Smith, Ellen Tein,  Lindsay Gurska, Robert Dubin, Jidong Shan, Kith Pradhan, Amit Verma, Cristina Montagna, and Kira Gritsman, Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells, Sci Adv. 2023 Feb 22;9(8):eade8222. doi: 10.1126/sciadv.ade8222. Epub 2023 Feb 22. PMID: 36812307

Gurska, L.M., Okabe, R., Schurer, A., Tong, M.M., Soto, M., Choi, D., Ames, K., Glushakow-Smith, S., Montoya, A., Tein, E., Miles, L.A., Cheng, H., Hankey-Giblin, P., Levine, R.L., Goel, S., Halmos, B., and Gritsman, K. Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms, Clinical Cancer Research 2022 Dec 20:CCR-22-1763. doi: 10.1158/1078-0432.CCR-22-1763. PMID: 36537918

Virginia Folgado Marco, Kristina Ames, Jacky Chuen, Kira Gritsman & Nicholas Baker, Haploinsufficiency of the essential gene RpS12 causes defects in erythropoiesis and hematopoietic stem cell maintenance, BioRxiv 2021, doi: (preprint); eLife (in press)

Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R.O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E.M., Zhao, J.J., Roberts, T.M., and Gritsman, K.,PI3 kinase alpha and delta promote hematopoietic stem cell activation, JCI Insight 2019 

Gurska, L., Ames, K., and Gritsman, K, Signaling Pathways in Leukemic Stem Cells, In: Zhang H., Li S. (eds) Leukemia Stem Cells in Hematologic Malignancies. Advances in Experimental Medicine and Biology, vol 1143. Springer, Singapore, July 24, 2019, doi:, PMCID: PMC7249489

Mitchell, K., Barreyro, L., Todorova, T., Taylor, S., Antony-Debre, I., Narayanagari, S., Carvajal, L., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., Gritsman, K., and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML, J Exp Med.2018 May 17. doi: 10.1084/jem.20180147, PMID: 29773641

Hemmati, S., Haque, T., and Gritsman, K, Inflammatory Signaling Pathways in Pre-leukemic and Leukemic Stem Cells, Frontiers Oncology2017 Nov 13;7:265. doi: 10.3389/fonc.2017.00265

Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L., Bronson, R., Roberts, T., Gritsman, K., and Zhao, J.J. A p110b-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis. Nature Communications October 7,2015, doi:10.1038/NCOMMS9501

Cheng, H., Zou, Y., Ross, J.S., Wang, K., Liu, X., Halmos, B., Ali, S.M., Liu, H., Verma, A., Montagna, C., Chachoua, A., Goel, S., Schwartz, E.L., Zhu, C., Shan, J., Yu, Y., Gritsman, K., Yelensky, R., Lipson, D, Otto, G., Hawryluk, M., Stephens, P.J., Miller, V.A., Piperdi, B., Perez-Soler, R., RICTOR amplification defines a novel subset of lung cancer patients who may benefit from treatment with mTOR1/2 inhibitors. Cancer Discovery, September 14, 2015; doi:10.1158/2159-8290.CD-14-0971

Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U. PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome. Blood. 2015 Jul 13. pii: blood-2014-12-618801.

Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S-C., Kim, S., Liu, H., Tivey, T., Christie, A.L., Gritsman, K., Gotlib, J., Deininger, M., Turley, S., Tyner, J., Marto, J., Weinstock, D.M., and Lane, A.A. Mutations in G-protein beta subunits promote transformation and kinase inhibitor resistance Nature Medicine 2015 (1):71-5.

Gritsman, K., Yuzugullu, H., Von, T., Yan, H., Clayton, L., Fritsch, C., Maira, S.-M., Hollingworth, G., Choi, C., Khandan, T., Paktinat, M., Okabe, R.O., Roberts, T.M., and Zhao, J.J. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha. Journal of Clinical Investigation 2014;124(4):1794–1809.

Kharas, M.G. and Gritsman, K. Akt: A Double-Edged Sword for Hematopoietic Stem Cells. Cell Cycle 2010; Vol 9; Issue 7

Kharas, M.G., Okabe, R., Ganis, J.J., Gozo,M., Khandan,T., Paktinat, M., Gilliland, D.G., and Gritsman, K. Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice. Blood 2010;115(7): 1406-15